Revolutionizing Metabolic Health with GLP1s: Tirzepatide vs. Retatrutide

July 19, 2023
By Dr. Arati Joshi,

A New Era of Metabolic Healthcare?


In recent news, there has been a lot of buzz surrounding drugs like Mounjaro, Ozempic, and Wegovy due to their association with Hollywood celebrities such as Elon Musk, Chelsea Handler, and Amy Schumer. While these drugs have gained popularity as “miracle weight loss” treatments, it is important to delve into the facts and figures behind them in order to make informed decisions about our health. In this blog, we will explore two innovative treatments that claim to have the potential to revolutionise metabolic health and redefine the management of metabolic conditions like type 2 diabetes.

Tirzepatide: A Metabolic Game-Changer:

Tirzepatide, initially developed as an injectable peptide for type 2 diabetes, has recently emerged as a groundbreaking weight loss medication. Its effectiveness in promoting weight reduction has far exceeded expectations. During extensive phase 3 clinical trials involving over 2,500 participants with obesity or overweight, Tirzepatide demonstrated remarkable results, leading to significant and sustained weight loss of 15-20% over 72 weeks.

Unveiling the Long-Term Effects and Safety:

To ensure any medication’s viability, assessing its long-term effects is crucial. Tirzepatide has demonstrated a favourable safety profile throughout clinical trials. Although mild to moderate gastrointestinal issues were the most common adverse events, they were mostly manageable. Treatment discontinuation rates were comparable to those of other weight loss medications, highlighting the potential for Tirzepatide as a safe and effective long-term solution for metabolic health.

Alleviating the Global Metabolic Health Burden:

The escalating prevalence of metabolic diseases like type 2 diabetes, hypertension, and non-alcoholic fatty liver disease has become a global health crisis. Addressing this burden requires effective interventions. Tirzepatide’s exceptional weight loss outcomes, coupled and improvements in cardiovascular and metabolic risk factors, offer hope in combating the global metabolic health crisis. By reducing the prevalence of these conditions, Tirzepatide can contribute significantly to the well-being of individuals worldwide.

Retatrutide: Pioneering Weight Loss Medication:

Eli Lilly’s experimental drug, Retatrutide, showcased in the latest ADA conference, has emerged as a potential game-changer in the field of weight loss medications. In mid-stage clinical trials, participants experienced a staggering average weight loss of 24%, equivalent to approximately 58 pounds. The extraordinary efficacy of Retatrutide positions it as a groundbreaking solution for individuals seeking effective weight management and metabolic health improvement.

Navigating the Path Ahead:

Although Retatrutide is still in its early developmental stages, its potential to surpass Tirzepatide’s weight loss efficacy is undeniable. Extensive research, including a large-scale phase 3 clinical trial slated for completion in late 2025, will shed more light on the drug’s effectiveness and safety profile. If successful, Retatrutide could revolutionize the weight loss landscape, potentially offering weight reduction comparable to bariatric surgery.

Balancing Long-Term Effects and Global Impact:

As with any novel medication, concerns about long-term effects and potential side effects arise. The remarkable speed of weight reduction associated with Retatrutide prompts careful consideration. Experts emphasize the importance of a healthy lifestyle in sustaining weight loss and minimizing any potential risks, such as gallstone formation. The ongoing exploration of these aspects will provide valuable insights into the long-term viability of Retatrutide as a metabolic health intervention.


In our professional opinion, obesity is the primary driver in developing type 2 diabetes and other complications. Healthy and sustainable weight loss itself gives better control of diabetes. Tirzepatide and Retatrutide are both effective options (keeping the side effects in mind) for managing type 2 diabetes with obesity. But it is important to consult your doctor in order to decide which treatment option is best for you considering your health and your health goals.

The development of Tirzepatide and Retatrutide represents a new era in weight loss medications. These drugs show some promise in combating obesity, improving metabolic health, and reducing the global metabolic health burden. While Tirzepatide has already achieved FDA approval for type 2 diabetes, Retatrutide’s weight loss results suggest a potential future breakthrough. As we wait for more research and clinical trials for long-term efficacy, sustainable behaviour change models can be relied upon for the management of these metabolic conditions.

In summary:

Aspects Tirzepatide Retatrutide
Mechanism of Action GLP-1 and GIP receptor agonist GLP-1, GIP, and glucagon receptor agonist
Indication Type 2 diabetes and obesity Weight loss (current research)
Weight Reduction Average of 15-20% over 72 weeks Average of 24% over 48 weeks
Long-Term Effects Favorable safety profile Requires further research and larger clinical trials
Common Adverse Events Gatrointestinal, gallbladder disease, kidney damage Side effects are mostly gastrointestinal based on the phase 2 trials
Future Potential Approved for type 2 diabetes and weight loss pending Requires completion of phase 3 trials and FDA review
Additional Applications Improvements in cardiovascular and metabolic risk factors Potential to treat obstructive sleep apnea and decrease heart disease risk


Chew, N. W. S., Ng, C. H., Tan, D. J. H., Kong, G., Lin, C., Chin, Y. H., . . . Muthiah, M. D. (2023). The global burden of metabolic disease: Data from 2000 to 2019. Cell Metabolism, 35(3), 414-428.e413. doi: https://doi.org/10.1016/j.cmet.2023.02.003

Jastreboff, A. M., Aronne, L. J., Ahmad, N. N., Wharton, S., Connery, L., Alves, B., . . . Stefanski, A. (2022). Tirzepatide Once Weekly for the Treatment of Obesity. New England Journal of Medicine, 387(3), 205-216. doi: 10.1056/NEJMoa2206038

Jastreboff, A. M., Kaplan, L. M., Frías, J. P., Wu, Q., Du, Y., Gurbuz, S., . . . Hartman, M. L. (2023). Triple–Hormone-Receptor Agonist Retatrutide for Obesity — A Phase 2 Trial. New England Journal of Medicine. doi: 10.1056/NEJMoa2301972

Lovelace Jr, B. (2023, June 26). Experimental drug could offer more weight loss than any drug now on the market, study finds. NBC News. https://www.nbcnews.com/health/health-news/experimental-drug-offer-weight-loss-drug-now-market-study-finds-rcna89702

Disclaimer: The information provided in this blog is based on research that has been conducted and published. It is important to note that the content of this blog should not be considered as medical advice. Smit.fit does not endorse or promote any specific brand name or pharmaceutical entity. It is strongly advised to consult with a healthcare professional and discuss any medical advice or decisions before taking any action.

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